CRYSTAL STRUCTURES OF P-SELECTIN, P- AND E-SELECTIN COMPLEXES, AND USES THEREOF

摘要

EP0105854nt invention relates to the crystal and three dimensional structure s of the lectin and EGF-like (LE) domains of P-selectin, the crystal and three dimensional structures of P-selectin LE and E-selectin LE each complexed wit h SLeX, as well as the crystal and three dimensional structure of P-selectin L E complexed with a functional PSGL-1 peptide modified by both tyrosine sulfati on and SLeX. The present invention also provides methods for identifying agents which activate or inhibitor each of the foregoing structures. In addition, t he present invention provides agents identified by such methods.