发明名称 ADENOVIRUS FORMULATIONS FOR GENE THERAPY.
摘要 <p>The present invention relates to a formulation allowing the preservation of viral particles and viral vectors, which is directly injectable into an organism. It relates more particularly to a formulation for the preservation of a recombinant adenovirus vector that optimally enhances the vector titer, or stabilizes the vector at refrigerator or room temperature, or both. The invention relates to compositions comprising a recombinant adenovirus vector and a concentration of human serum albumin (HSA) effective to stabilize the adenovirus vector at a temperature above the freezing point of water or to enhance a titer of the adenovirus vector compared to a titer in the absence of HSA, or both, in an aqueous buffer.</p>
申请公布号 MXPA01001727(A) 申请公布日期 2001.11.27
申请号 MX2001PA01727 申请日期 1999.08.13
申请人 AVENTIS PHARMACEUTICALS PRODUCTS INC. 发明人 SHIH, SHIAN-JIUN
分类号 C12N15/09;A61K35/76;A61K38/00;A61K47/10;A61K47/26;A61K48/00;A61P9/00;A61P25/00;A61P35/00;C12N15/86;C12N15/861;(IPC1-7):A61K35/00;C12N15/00;C07H21/04;C12N15/63 主分类号 C12N15/09
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