Decoquinate, 4-hydroxyquinolones and napthoquinones for the prevention and treatment of equine protozoal myeloencephalitis caused by sarcocystis neurona hughesiand other apicomplexan protozoans

摘要

Apicomplexan parasites such as Sarcocystis neurona and Neospora hughesi may be killed with decoquinate, a 4-hydroxyquinolone and/or a naphthoquinone. Based on such parasite-killing activity, these compounds are used in methods of preventing and treating neurological disease or dysfunction such as protozoal myeloencephalitis, especially EPM.