发明名称 Cyclohexyl derivatives and their use as therapeutic agents
摘要 The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>7</SUP>, R<SUP>13</SUP>, R<SUP>14</SUP>, R<SUP>15</SUP>, R<SUP>16</SUP>, R?17, R<SUP>18</SUP>, R<SUP>19</SUP>, R<SUP>21a </SUP>and R<SUP>21b </SUP>are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
申请公布号 AU5650501(A) 申请公布日期 2001.11.26
申请号 AU20010056505 申请日期 2001.05.16
申请人 MERCK SHARP AND DOHME LIMITED 发明人 JOSE LUIS CASTRO PINEIRO;KEVIN DINNELL;JASON MATTHEW ELLIOTT;GREGORY JOHN HOLLINGWORTH;DUNCAN EDWARD SHAW;CHRISTOPHER JOHN SWAIN;LIHU YANG
分类号 C07D295/04;A61K31/075;A61K31/12;A61K31/135;A61K31/16;A61K31/165;A61K31/215;A61K31/341;A61K31/357;A61K31/40;A61K31/403;A61K31/41;A61K31/4164;A61K31/4196;A61K31/4355;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4453;A61K31/451;A61K31/472;A61K31/495;A61K31/496;A61K31/5375;A61K31/54;A61K31/55;A61P1/08;A61P25/04;A61P25/06;A61P25/22;A61P25/24;A61P29/00;A61P43/00;C07C43/178;C07C45/29;C07C49/497;C07C49/517;C07C49/697;C07C49/747;C07C49/753;C07C69/757;C07C69/767;C07C217/48;C07C217/52;C07C229/22;C07C233/23;C07C233/31;C07C233/32;C07C233/58;C07C233/59;C07C235/40;C07C235/80;C07C235/82;C07C237/04;C07C237/08;C07C237/24;C07D207/06;C07D207/16;C07D211/14;C07D211/18;C07D211/22;C07D211/38;C07D211/42;C07D211/46;C07D211/48;C07D211/58;C07D211/62;C07D211/70;C07D211/74;C07D213/38;C07D217/04;C07D233/90;C07D241/08;C07D257/04;C07D265/30;C07D275/04;C07D277/28;C07D295/08;C07D295/096;C07D295/14;C07D295/15;C07D295/155;C07D295/185;C07D295/192;C07D295/205;C07D307/52;C07D317/72;C07D333/20;C07D401/04;C07D401/06;C07D413/04;C07D417/12;C07D487/08;C07D491/20 主分类号 C07D295/04
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