| 摘要 |
The invention relates to a biocompatible, bio- resorbable and non-toxic adhesive composition for surgical use, for the bonding, in particular, of biological tissues to one another or to an implanted biomaterial, characterized in that it comprises a reactive acidic solution of non-crosslinked and potentially crosslinkable collagen or gelatin modified by oxidative cleavage, at a concentration which is prefer- ably between approximately 5 and 30% by weight. It also relates to reactive acidic solutions and powders based on non-crosslinked collagen or gelatin modified by oxidative cleavage which are used as inter- mediate products in the preparation of the abovementioned composition, and to the process for their preparation. It also relates to adhesive kits which comprise, on the one hand, the abovementioned reactive acidic solution and, on the other hand, a neutralizing solution and which are intended for extemporaneous mixing. Finally it relates to a method of application of the adhesive composition according to the invention. The invention is particularly useful in the areas of adhesion, haemostasis, leaktightness with respect to liquids or gases, cicatrization, filling, avoiding adhesion in surgery, embolization, as a local system for release of medicamentary active principles, etc.
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