发明名称 |
Methods and compounds for modulating melanocortin receptor ligand binding and activity |
摘要 |
This invention relates to methods and agonist/antagonist compounds for modulating melanocortin receptor-ligand binding. Also included is a method of identifying agonists and/or antagonists that bind to a ligand binding site for a melanocortin receptor of interest. Agonists and antagonists of ligand binding to melanocortin receptors also are provided. The invention is exemplified by identification and manipulation of the C-terminus of the human agouti related protein, which binds melanocortin receptors 3 and 4, and the prodution of AGRP peptidomimetics that are melanocortin receptor ligands. The methods can be applied to other melanocortin receptor agonists and antagonists. |
申请公布号 |
AU6136301(A) |
申请公布日期 |
2001.11.20 |
申请号 |
AU20010061363 |
申请日期 |
2001.05.08 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, |
发明人 |
GLENN L. MILLHAUSER;DARREN A. THOMPSON;KIMBERLEY A. BOLIN;D. JOE ANDERSON;JOSEPH C. MCNULTY |
分类号 |
A61K38/00;C07K5/06;C07K5/083;C07K14/47;C12N5/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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