A compressed tablet composition comprising:a granular component comprising a plurality of solidified melt granules of a non-steroidal anti-inflammatory drug (NSAID) having a melting point in the range 30-300 DEG C and incorporating a disintegrant uniformly dispersed therein; characterised in that the granules comprise a continuous phase of said non-steroidal anti-inflammatory drug and further characterised in that the tablet composition comprises silicon dioxide present in an amount of 0.05-5.0 % by weight of the composition. Preferably, the composition also contains an extra-granular component comprising the silicon dioxide and a lubricant. Further preferably the NSAID is ibuprofen which has a melting point in the range 75-77 DEG C. Optionally the melting process can be carried out in an extruder. Tablets containing advantageous processing properties and dissolution characteristics are obtained.
申请公布号
WO0141733(A3)
申请公布日期
2001.11.15
申请号
WO2000EP12193
申请日期
2000.11.30
申请人
THE BOOTS COMPANY PLC;SHERRY, ROBERT, ARTHUR;RHOADES, TRACEY, JANE;HIGTON, FREDERICK, RAYMOND
发明人
SHERRY, ROBERT, ARTHUR;RHOADES, TRACEY, JANE;HIGTON, FREDERICK, RAYMOND