| 摘要 |
<p>Solid oral pharmaceutical composition comprising bisphosphonic acid derivative contains the cores based on a carbohydrate alcohol, preferably mannitol, uniformly dispersed in a homogenous blend of an active ingredient and excipients. The process of preparation of the above pharmaceutical formulation is also disclosed. The invention is particularly suitable to prepare solid oral dosage forms of the medicines comprising alendronic acid derivative, especially alendronic acid monosodium salt trihydrate.</p> |
