Process for preparing 2-phenyl-3-aminopyridine, substituted phenyl derivatives thereof, and salts thereof.

摘要

A process for preparing 2-phenyl-3-aminopyridine, and substituted phenyl derivatives and salts thereof. A compound of the formula is reacted with a compound of the formula in a reaction inert solvent in the presence of a base and a palladium catalyst to obtain a compound of the formula Preferably, the compound of formula III or VIII is prepared by reacting a compound of the formula with a compound of the formula or ArCHO in a reaction inert solvent. The compound of formula V is preferably deprotected in aqueous acid to obtain a salt of compound X. X, Y, Z, Ar, R<1>, R<2>, R<3>, R<4> and R<5> are as defined herein.