RH116 POLYPEPTIDES AND ITS FRAGMENTS AND POLYNUCLEOTIDES ENCODING SAID POLYPEPTIDES AND THERAPEUTIC USES

摘要

The invention concerns a novel 116 kDa polypeptide exhibiting homologies of sequences with RNA helicases (DEXH box) called RH116 and its fragments, the cloning of cDNA and the polynucleotides encoding said polypeptides, cloning and/or expression vectors including said polynucleotides, cells transformed by said vectors and specific antibodies directed against said polypeptides. The invention also concerns methods for detecting and/or assaying said polypeptides and polynucleotides, corresponding diagnosis kits, and a method for screening ligands, as well as compounds for use as medicine for preventing and/or therapeutic treatment.