发明名称 |
Assay for emetic activity |
摘要 |
An assay for emetic activity among inhibitors of type 4 phosphodiesterase (PDE 4) is disclosed. The assay comprises:(A) administering to a test mammal an anesthetic compound in an amount sufficient to cause an anesthetic effect;(B) administering to the test mammal a test compound that has PDE 4 inhibitory activity;(C) observing the test mammal for changes in the anesthetic effect, and(D) correlating any change in the anesthetic effect observed in the anesthetized test mammal to a standard.
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申请公布号 |
US6316434(B1) |
申请公布日期 |
2001.11.13 |
申请号 |
US20000512513 |
申请日期 |
2000.02.24 |
申请人 |
MERCK FROSST CANADA & CO. |
发明人 |
ROBICHAUD ANNETTE;SAVOIE CHANTAL;CHANG CHI CHUNG |
分类号 |
A61K49/00;(IPC1-7):A01N43/00;A01N43/40;A01N61/00;C12Q1/68;G01N3/543 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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