Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes

摘要

Nucleic acid constructs containing HIV-1 gag/pol and SIV gag or SIV genes which have been mutated to remove or reduce inhibitory/instability sequences are disclosed. Viral particles and host cells containing these constructs and/or viral particles are also disclosed. The exemplified constructs and viral particles of the invention may be useful in gene therapy for numerous disorders, including HIV infection, or as a vaccine for HIV-1 immunotherapy and immunoprophylaxis.