| 摘要 |
The present invention describes a direct interaction between phosphorylated GPIIIa cytoplasmic domains with 1) <i>src/</i>non-<i>src</i> family kinases and 2) phosphatases. The invention provides methods for identifying agents that block GPIIIa interactions with <i>src/</i>non-<i>scr</i> family kinases and phosphatases, methods of using agents that block GPIIIa interactions with <i>src/</i>non-<i>src</i> family kinases and PIP-1C phosphatases to modulate biological and pathological processes and agents that block GPIIIa mediated binding to <i>src/</i>non-<i>scr</i> family kinases and PIP-1C phosphatases, thereby modulating related GPIIIa mediated signaling. |
