Random peptides that bind to gastro-intestinal tract (GIT) transport receptors and related drug delivery methods

摘要

Proteins (e.g., random peptides and peptide motifs) capable of facilitating transport of an active agent through human or animal gastro-intestinal tissue, and derivatives (e.g., fragments and functionally active analogues) thereof, and nucleotide sequences coding for said proteins and derivatives are disclosed. The proteins facilitate transport of active agents from the lumenal side of the gastro-intestinal tract (GIT) into the systemic blood system and/or in targeting active agents to the GIT. Thus, by binding (covalently or noncovalently) a protein disclosed to an orally administered drug, the drug can be targeted to specific receptors, such as, HPT1, hEPT1, D2H and hSI, or transport pathways which are known to operate in the human GIT.