发明名称 |
SELF-EXTINGUISHING RECOMBINASES, NUCLEIC ACIDS ENCODING THEM AND METHODS OF USING THE SAME |
摘要 |
Nucleic acid molecules comprising at least a first signal site and a recombinase gene operably linked to an expression control sequence, such that upon entry into a cell, there is a first signal site and a second signal site positioned to mediate excision of a sufficient portion of either the recombinase gene or the expression control sequence to extinguish recombinase activity when the first and second signal sites are contacted with a recombinase, cells, transgenics and uses of the foregoing. |
申请公布号 |
WO0179471(A2) |
申请公布日期 |
2001.10.25 |
申请号 |
WO2001US12193 |
申请日期 |
2001.04.12 |
申请人 |
DANA-FARBER CANCER INSTITUTE;LIVINGSTON, DAVID, M.;SILVER, DANIEL, P. |
发明人 |
LIVINGSTON, DAVID, M.;SILVER, DANIEL, P. |
分类号 |
A61K48/00;C12N9/00;C12N15/10;C12N15/82;C12N15/90 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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