| 摘要 |
This invention relates to a compound of formula I:or a pharmaceutically acceptable salt thereof; in which preferably R3, R4 and R6 are each hydrogen;X is C=O or CH2; andR7 and R8 are each independently selected from the group consisting of hydrogen, (C1-C12)alkyl, (C3-C8)cycloalkyl and (C1-C12)alkyl(C6-C14)aryl; orR7 and R8 when taken together form a (C2-C7)alkylene group; or-NR7R8 together forms a (C2-C14)heterocyclic or substituted (C2-C14)heterocyclic. Such compounds modulate the activity of serine hydrolases and can be used in pharmaceutical compositions for the treatment of Alzheimer's disease. |
