发明名称 |
Deregulation of glutamine PRPP amidotransferase activity |
摘要 |
The present invention is directed to a modified glutamine PRPP amidotransferase and a method of using that modified enzyme to enhance the biosynthesis of purine nucleotides. The modified glutamine PRPP amidotransferase has at least one amino acid of the allosteric A sites or the catalytic C sites of said amidotransferase substituted with a non-native amino acid, wherein the substitution reduces the sensitivity of the enzyme to end product inhibition relative to the native glutamine PRPP amidotransferase enzyme.
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申请公布号 |
US2001031486(A1) |
申请公布日期 |
2001.10.18 |
申请号 |
US20010805294 |
申请日期 |
2001.03.13 |
申请人 |
ZALKIN HOWARD;SMITH JANET L.;SWITZER ROBERT L. |
发明人 |
ZALKIN HOWARD;SMITH JANET L.;SWITZER ROBERT L. |
分类号 |
C12N1/21;C12N9/10;C12N15/54;C12P19/32;(IPC1-7):C12P19/30 |
主分类号 |
C12N1/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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