| 摘要 |
A method of producing a melanin comprises oxidizing a phenolic compound at one or more hydroxyl groups thereof, wherein the phenolic compound is selected from 5-hydroxyindole and derivatives thereof and compounds of formula (1) and the oxidation is provided by biotransformation in the presence of an oxidoreductase enzyme, the compound of formula (1),wherein R1 is H or OH; R2 is H, OH orOCH3; R3 is H or OH at least one of R1 and R3 being OH; R4 is selected from H , R, -COOX and R7-COOX, wherein R is an optionally substituted saturated or unsaturated alkyl group having from 1 to 12 carbon atoms, R7 is an optionally substituted saturated or unsaturated alkylene group having from 1 to 12 carbon atoms and X is selected from H and aliphatic and aromatic ester forming groups; and R5 and R6 is each independently selected from H, OH, NH2, OCH3, CH3, SH, NHCO2, NHCH3, COOH and saturated or unsaturated alkyl groups having up to 8 carbon atoms.
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