发明名称 |
Compositions and methods for tissue specific gene regulation therapy |
摘要 |
This invention relates to a recombinant nucleic acid vector comprising a first expression cassette comprising a first promoter operably linked to a nucleic acid sequence encoding a syncytium-inducing polypeptide, wherein the first expression cassette is flanked on either side by a site recognized by a recombinase. The invention also includes a second expression cassette comprising a tissue-specific promoter operably linked to a nucleic acid sequence encoding a recombinase. The invention also includes cells and compositions including these expression cassettes and methods of reducing tumor volume by expression of these expression cassettes. |
申请公布号 |
AU5113801(A) |
申请公布日期 |
2001.10.15 |
申请号 |
AU20010051138 |
申请日期 |
2001.03.30 |
申请人 |
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
RICHARD G. VILE;KEVIN HARRINGTON;STEPHEN MURPHY;ANDREW BATEMAN |
分类号 |
A61K48/00;C12N15/867 |
主分类号 |
A61K48/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|