| 发明名称 |
MOLECULAR STRUCTURE OF <i>RHD</i> NEGATIVE |
| 摘要 |
<p>The present invention relates to a nucleic acid molecular structure representing the Rhesus genes locus comprising the <i>RHD, SMP1</i> and <i>RHCE</i> genes and/or the <i>Rhesus box(es)</i>, preferably the hybrid <i>Rhesus box</i>, the upstream <i>Rhesus box</i> and/or the downstream <i>Rhesus box</i>. Furthermore, the invention relates to a process for the specific detection of the common <i>RHD</i> negative haplotypes. The invention further relates to the detection of <i>RHD</i> positive hyplotypes in D-negative individuals. Various mutations in the <i>RHD</i> gene have been identified that allow for the development of diagnostic tools. The invention also relates to oligonucleotides, that specifically hybridize to the hybrid box, preferably the breakpoint or breakpoint region or to the upstream and downstream <i>Rhesus boxes</i>. Additionally, the invention relates to kits comprising or employing the above recited compounds of the invention.</p> |
| 申请公布号 |
WO0132702(A9) |
申请公布日期 |
2001.10.11 |
| 申请号 |
WO2000EP10745 |
申请日期 |
2000.10.31 |
| 申请人 |
DRK BLUTSPENDEDIENST BADEN-WUERTTEMBERG GMBH;FLEGEL, WILLY, A.;WAGNER, FRANZ, F. |
发明人 |
FLEGEL, WILLY, A.;WAGNER, FRANZ, F. |
| 分类号 |
G01N33/53;A61K39/395;A61P15/00;C07K14/47;C07K14/705;C07K16/18;C12N5/10;C12N7/00;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12Q1/02;C12Q1/68;G01N33/566;(IPC1-7):C07K14/47 |
主分类号 |
G01N33/53 |
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