| 摘要 |
A compressed, sustained release oral pharmaceutical preparation, e.g. a tablet, comprises a water-granulated mixture of polyvinyl-pyrrolidone, a hydrophobic fatty acid salt and a therapeutically active material, the composition containing at least about 5% by weight of P.V.P. and the weight ratio of P.V.P. to fatty acid salt being from 1 to about 1 to 1 to about 4. Of the therapeutically active material is water-insoluble, a hydrophilic gum, e.g. carboxymethylcellulose, other methylcelluloses and their sodium salts, gelatin, ueacia and alginates may also be present. The P.V.P. is preferably one having a K value of from about 24 to about 40 and a molecular weight of from about 20,000 to about 100,000. Specified fatty acid salts are those of Al, Ca and Mg. Specified medicaments are chlorzoxazone, antihistamines, e.g. carbinoxamine and rotoxamine, antispasmodics, e.g. poldine, central nervous system depressants, e.g. phenobarbital and butylbarbital, central nervous system stimulants, e.g. methamphetamine, vasodilators, e.g. phenylpropanolamine and phenylephrine, vitamins, e.g. thiamine and pyridoxine and antibiotics, e.g. tetracycline, chlortetracycline, oxytetracycline and penicillins. |
