| 摘要 |
This invention relates to polymorphisms in the human pyruvate dehydrogenase kinase isoenzyme 2(PDK2) gene, in particular to the discovery of a single nucleotide polymorphism in the coding region of the human PDK2 gene and two single nucleotide polymorphisms in the 3' untranslated region of the human PDK2 gene. The invention also relates to methods and materials for analysing allelic variation in the PDK2 gene, and to the use of PDK2 polymorphism in the diagnosis and treatment of diseases in which inhibition of PDK2 could be of therapeutic benefit, such as diabetes, obesity and sepsis. |
