| 摘要 |
The present invention relates to FTCD antigen which is liver specific to serve as a diagnostic tool for Autoimmune Hepatitis type II. There is provided a human liver specific FTCD antigen recognized by LC1 antibodies which essentially consists in the amino acid sequence of SEQ ID NOS:3 and 4 or variants thereof which are recognized by LC1 antibodies. There is also disclosed a method of diagnosis of Autoimmune Hepatitis (AIH) type II disease in a patient biological sample, which comprises the steps of: a) subjecting a Western Blot having bound thereto an FTCD antigen of the present invention with the patient biological sample; and b) detecting the presence of LC1 antibodies in the sample; whereby the presence of LC1 antibodies is indicative of AIH type II disease.
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