发明名称 |
Computer system and method for determining a number of primary targets of a drug |
摘要 |
This invention relates to methods and systems for characterizing the actions of drugs in cells. In particular, the invention provides methods for identifying multiple primary targets through which a drug, drug candidate, or other compound of interest acts on a cell. Thus, the invention also relates to methods for drug development based on the disclosed methods for identifying multiple primary targets of a drug. The methods of the invention involve: (i) measuring responses of cellular constituents to graded exposures of the cell to a drug of interest; (ii) identifying an "inflection concentration" of the drug for each cellular constituent measured; and (iii) identifying "expression sets" of cellular constituents from the distribution of the inflection drug concentrations. Each expression set corresponds to a particular primary target of the drug. The invention also provides computer systems which identify multiple targets of a drug by executing the disclosed methods.
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申请公布号 |
US6300078(B1) |
申请公布日期 |
2001.10.09 |
申请号 |
US20000693642 |
申请日期 |
2000.10.20 |
申请人 |
ROSETTA INPHARMATICS, INC. |
发明人 |
FRIEND STEPHEN H.;STOUGHTON ROLAND |
分类号 |
G01N33/50;C12Q1/02;C12Q1/68;G01N33/15;G01N37/00;G06F19/00;(IPC1-7):C12Q1/68;G01N33/53;G01N33/567;G06F9/00 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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