| 发明名称 |
MEANS FOR THE MODULATION OF PROCESSES MEDIATED BY RETINOID RECEPTORS AND COMPOUNDS USEFUL THEREFOR |
| 摘要 |
In accordance with the present invention, there are provided methods to modulate processes mediated by retinoid recep- tors, employing high affinity, high specificity ligands for such receptors. In one aspect of the present invention, there are provided ligands which are more selective for the retinoid X receptor than is retinoi c acid (i.e., rexoids). In another aspect of the present invention, alternative ligands (other than retinoic acid) have been discover ed which are capable of inducing retinoic acid receptor mediated processes. In yet another aspect, methods have been developed for t he preparation of such retinoid receptor ligands from readily available compounds.
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| 申请公布号 |
CA2123223(C) |
申请公布日期 |
2001.10.09 |
| 申请号 |
CA19922123223 |
申请日期 |
1992.12.18 |
| 申请人 |
BAYLOR COLLEGE OF MEDICINE;THE SALK INSTITUTE FOR BIOLOGICAL STUDIES;LIGAND PHARMACEUTICALS, INC. |
发明人 |
EVANS, RONALD M.;MANGELSDORF, DAVID J.;BOEHM, MARCUS F.;EICHELE, GREGOR;THALLER, CHRISTINA;HEYMAN, RICHARD A. |
| 分类号 |
G01N33/566;A61K31/07;A61K31/19;A61K31/20;A61K31/203;A61K31/23;A61K31/232;A61K38/52;A61P3/06;A61P35/00;A61P43/00;C07C57/26;C07C59/46;C07C59/80;C07C403/00;C07C403/20;C07K14/705;C12P7/04;C12P7/62;C12P7/64;C12P9/00;(IPC1-7):C12P41/00 |
主分类号 |
G01N33/566 |
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