| 发明名称 |
METHODS RELATED TO IMMUNOSTIMULATORY NUCLEIC ACID-INDUCED INTERFERON |
| 摘要 |
Methods and compositions are provided for extending the clinical utility of IFN- alpha in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN- alpha treatment and reduce IFN- alpha treatment-related side effects. In addition, methods are provides for supporting the survival and for activating natural interferon producing cells (IPCs)<i>in vitro</i> without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.
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| 申请公布号 |
WO0122990(A3) |
申请公布日期 |
2001.10.04 |
| 申请号 |
WO2000US26527 |
申请日期 |
2000.09.27 |
| 申请人 |
COLEY PHARMACEUTICAL GROUP, INC.;UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
HARTMANN, GUNTHER;BRATZLER, ROBERT, L.;KRIEG, ARTHUR |
| 分类号 |
A61K31/7088;A61K35/12;A61K38/00;A61K38/21;A61P1/00;A61P1/08;A61P1/16;A61P29/00;A61P31/12;A61P31/18;A61P31/22;A61P35/00;A61P35/02;A61P37/04;A61P43/00;C12N5/0784;C12N15/117;(IPC1-7):A61K38/21;A61K35/28;C12N5/08 |
主分类号 |
A61K31/7088 |
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