发明名称 |
Extraction of the anthelmintic santonin from Artemisia plants, comprises extraction with a non-polar solvent, partitioning between hexane-ethyl acetate and aqueous polar phase and chromatographing on silica gel |
摘要 |
Extraction and isolation of santonin (I) from Artemisia comprises extracting air-dried, powdered above-ground parts of the plants; concentrating under reduced pressure; dissolving the residue in hexane-ethyl acetate; removing water from the polar phase; drying the polar component over anhydrous sodium sulfate; removing the solvent from the (I)-containing fractions; and crystallizing pure (I). Extraction and isolation of santonin (I) from Artemisia plants comprises: (a) extracting air-dried, powdered above-ground parts of the plants with a non-polar solvent in a Soxhlet apparatus in a ratio of 1:6; (b) concentrating the extract under reduced pressure; (c) dissolving the residue in hexane-ethyl acetate (7:3 to 9:1) and partitioning using an aqueous polar phase; (c) removing water from the polar phase by adding sodium chloride at 5-8 g per 100 ml; (d) drying the polar component over anhydrous sodium sulfate, concentrating and chromatographing on silica gel, eluting with n-hexane followed by n-hexane/ethyl acetate (5:5 to 7:3); (e) removing the solvent from the (I)-containing fractions; and (f) crystallizing pure (I).
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申请公布号 |
DE10014670(A1) |
申请公布日期 |
2001.10.04 |
申请号 |
DE20001014670 |
申请日期 |
2000.03.24 |
申请人 |
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH, NEU DEHLI |
发明人 |
JAIN, DHARAM CHAND;SAXENA, SUDHANSHU;SHAWL, ABDUL SAMI;BINDRA, RATTAN LAL;KUMAR, SUSHIL |
分类号 |
C07D307/92;(IPC1-7):C12P17/04;A61K31/365 |
主分类号 |
C07D307/92 |
代理机构 |
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