发明名称 AMPHIPHILIC QUINOLYLPOLYAMINES AS TRANSFER AGENTS FOR BIOLOGICALLY ACTIVE MACROMOLECULES
摘要 The invention relates to amphiphilc amines and the salts thereof, which may complex with biopolymers such as DNA, RNA, anti-sense oligonucleotides, ribozymes, proteins and peptides and transfer them into eucaryotic cells. Polyaminochinoline derivatives, which are modified with lipophilic groups are a particularly suited substance class. According to the invention, due to the property of forming aggregates with biologically active molecules such as, for example, DNA or RNA, said compounds are particularly suitable for use in gene therapy and, equally, for diagnostic purposes.
申请公布号 WO0144198(A8) 申请公布日期 2001.10.04
申请号 WO2000DE04443 申请日期 2000.12.13
申请人 G.O.T. GESELLSCHAFT FUER THERAPIEOPTIMIERUNG UND TARGETING ENTWICKLUNGS MBH;KEIL, OLIVER 发明人 KEIL, OLIVER
分类号 A61K9/127;A61K31/7105;A61K31/711;A61K38/00;A61K45/00;A61K47/22;A61K47/24;A61K47/26;A61K47/28;A61K47/34;A61K47/48;A61K48/00;C07D215/46;C07J9/00;C12N15/88;(IPC1-7):C07D215/46;C12N15/87;A61K31/47 主分类号 A61K9/127
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