发明名称 |
METHOD FOR PREPARING 9-DEOXO-8A-AZA-(8A-ALKYL)-8A-HOMOERYTHROMYCIN A DERIVATIVES FROM 9-DEOXO-9(Z)-HYDROXYIMINOERYTHROMYCIN A |
摘要 |
The invention concerns a method for preparing 9-deoxo-8a-aza-(8a-alkyl)-8a- homoerythromycin A and its 8a-alkyl derivatives from 9-deoxo-9(Z)- hydroxyiminoerythromycin A via a Beckmann stereospecific rearrangement in a reaction medium using pyridine as main solvent, leading to imidate intermediates which are not isolated from said medium and which are directly engaged in a reduction step using a sufficient amount of borohydride, after extracting the pyridine with a hydrocarbon miscible therewith and wherein sa id imidates are insoluble. The compound (V) can be directly N-alkylated in position-8a, using an aldehyde, without being isolated from the reduction medium.
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申请公布号 |
CA2399634(A1) |
申请公布日期 |
2001.10.04 |
申请号 |
CA20012399634 |
申请日期 |
2001.03.23 |
申请人 |
MERIAL |
发明人 |
ODDON, GILLES;PAUZE, DENIS;LEON, PATRICK;LHERMITTE, FREDERIC |
分类号 |
C07H17/00;C07H17/08;(IPC1-7):C07H17/08 |
主分类号 |
C07H17/00 |
代理机构 |
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代理人 |
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地址 |
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