| 摘要 |
The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof: <CHEM> wherein R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents a hydrogen atom or 1 to 3 substituents selected from a C 1-6 alkyl group, halogen atom, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a hydroxyl group, a C1-6 alkoxy group, methylenedioxy group, a nitro, a cyano, an amino, a C1-6 monoalkylamino group, C2-10 dialkylamino group ; C1-6 alkylcarbonylamino group, C6,10 arylcarbonylamino group; R3 represents a 2, 3 or 4-pyridyl group optionally substituted by a C1-4 alkyl group, C1-4 alkoxy group or a halogen atom and n represents 0 or 1, when n represents 0 then m is 2 or 3, and when n represents 1 then m is 1 or 2. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3 beta such as Alzheimer's disease, Parkinson's disease, frontoparietal dementia, corticobasal degeneration, Pick's disease, cerebrovascular accidents and brain and spinal trauma and peripheral neuropathies. |
