发明名称 |
Adenovirus-medicated gene transfer to cardiac and vascular smooth muscle |
摘要 |
The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus virus vector construct intravascularly.
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申请公布号 |
US6297220(B1) |
申请公布日期 |
2001.10.02 |
申请号 |
US19970972831 |
申请日期 |
1997.11.18 |
申请人 |
ARCH DEVELOPMENT CORPORATION |
发明人 |
LEIDEN JEFFREY M.;BARR ELIAV |
分类号 |
C12N15/09;A61K31/7088;A61K35/76;A61K38/00;A61K38/22;A61K45/00;A61K48/00;A61P9/10;C07K14/47;C12N5/10;C12N15/12;C12N15/861;C12P21/00;C12R1/91;(IPC1-7):C12N7/00;C12N7/04;C12N15/63;A01N43/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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