4,5-diaryl-3( 2H )-furanone derivatives as cyclooxygenase-2 inhibitors

摘要

The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation, inflammation-associated disorders, and COX-2 mediated diseases.