<i>NUSAP</i>, A NOVEL GENE ENCODING A TISSUE-SPECIFIC NUCLEAR PROTEIN, USEFUL AS A DIAGNOSTIC TOOL AND THERAPEUTIC AGENT

摘要

The invention relates to a eukaryotic nuclear protein NuSAP which is highly expressed in proliferation tissues. More specifically, NuSAP is downregulated in developing bone. NuSAP has a discrete localization in the nucleus. The localization and the expression profile indicate its role in important biological processes such as embryologic development, cell, proliferation, DNA replication and recombination. Its function relates to diseases of the immune system and diseases of the reproductive organs in particular and cancer in general.