The present invention provides that an endogenous opioid peptide, OGF, inhibits angiogenesis <i>in vivo</i> via acting on OGF receptor. The present invention also provides that opioid antagonist naltrexone and naltrexone stimulated blood vessel development. Therapeutic compositions and methods for modulating angiogenesis are provided.
申请公布号
WO0170031(A1)
申请公布日期
2001.09.27
申请号
WO2001US40365
申请日期
2001.03.23
申请人
ZAGAN, IAN, S.;BLEBEA, JOHN;MCLAUGHLIN, PATRICIA, J.
发明人
ZAGAN, IAN, S.;BLEBEA, JOHN;MCLAUGHLIN, PATRICIA, J.
