PYRAZOLINE DERIVATIVES OR TETRAHYDROPYRIDAZINE DERIVATIVES AND MEDICINAL USE THEREOF

摘要

Drugs which have an effect of activating glutamic acid transporter and are useful as preventives and/or remedies for ischemic brain failures (brain infarction, brain edema), amyotrophic lateral sclerosis (ALS), etc. caused by glutamic acid toxicity are provided by using a compound selected from among compounds represented by the general formula (1), including 3-phenyl-2-pyrazoline derivatives and 3-phenyl-tetrahydropyridazine derivatives, and pharmaceutically acceptable salts thereof.