发明名称 |
Inflammation-inducible hybrid promoters, vectors containing same and uses thereof |
摘要 |
The invention concerns gene expression regulating and is based particularly on the use of constructs enabling to activate transcription of a transgene in cells, tissues or organs in inflammatory condition. The inventive promoters preferably contain: a) an element of response to a PPAR and b) all or part of a promoter of gene PLA2sIIA. The invention also concerns vectors, cells and compositions comprising said promoters and their use for regulating expression of genes in vitro, ex vivo or in vivo. |
申请公布号 |
AU3939201(A) |
申请公布日期 |
2001.09.24 |
申请号 |
AU20010039392 |
申请日期 |
2001.03.14 |
申请人 |
AVENTIS PHARMA S.A. |
发明人 |
CHARBEL MASSAAD;FRANCIS BERENBAUM;JEAN-LUC OLIVIER;COLETTE SALVAT;GILBERT BEREZIAT |
分类号 |
C12N15/09;A61P19/02;A61P29/00;C07K14/705;C07K14/78;C12N9/20;C12N15/12;C12N15/63;C12N15/85 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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