| 摘要 |
<p>A biological evaluation method for rationally and simply evaluating biological harmfulness or efficacy of a great number of natural and artificial chemicals, foods, etc. This method comprises adding a known amount of 2'-deoxyguanosine (dG) to a solution containing a test substance (drug, pesticide, functional food, etc.), optionally irradiating with UV light and/or adding an active oxygen generator, then quantifying 8-hydroxy-2'-deoxyguanosine (8OHdG) in the above solution, and evaluating the toxicity or efficacy of the above test substance depending on the 8OHdG content (a higher 8OHdG content indicates a higher harmfulness of the test substance while a lower 8OHdG content indicates a lower harmfulness or an efficacy thereof). An apparatus for advantageously carrying out the above biological evaluation method and an antioxidant preservative solution to be used in this apparatus are provided.</p> |
