发明名称 |
Homogeneous preformulations containing high concentrations of steroids, for producing low-dose solid and semi-solid pharmaceutical preparations |
摘要 |
A homogeneous steroid-containing preformulation for production of solid and semi-solid pharmaceutical preparations containing a uniform constant dosage of at least one steroid in a range from 0.001 to 1 percent by weight is described. This steroid-containing preformulation contains of from 0.001 to 50 percent by weight of the at least one steroid. The homogeneous steroid-containing preformulation is made by a method including dissolving the at least one steroid in a solvent to form a dispersant; dispersing an adjuvant consisting of adjuvant particles in the dispersant in a mass ratio of the adjuvant to the at least one steroid of 1:1 to 1000:1 to form a suspension; and creating a spray-mist of the suspension so as to evaporate and remove the solvent from the suspension and thus to form a dried particulate which includes steroid-containing particles. The droplets in the spray mist have a droplet diameter greater than a mean diameter of the adjuvant particles. The maximum particle size of the dried particulate forming the steroid-containing preformulation is increased by less than 30 percent in comparison to an average particle size of the adjuvant particles.
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申请公布号 |
US6290931(B1) |
申请公布日期 |
2001.09.18 |
申请号 |
US19990319802 |
申请日期 |
1999.06.10 |
申请人 |
JENAPHARM GMBH & CO. KG |
发明人 |
GRAWE DETLEF;HOESEL PETER;MOELLMANN PETER;TIMPE CARSTEN;DITTGEN MICHAEL;MATTHEY KLAUS |
分类号 |
A61K9/14;A61K9/16;A61K9/20;A61K31/56;A61K31/567;(IPC1-7):A61K9/12 |
主分类号 |
A61K9/14 |
代理机构 |
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地址 |
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