A screening method for identifying a drug-like compound or lead compound for the development of a drug-like compound in which (1) a xanthine or related compound is exposed to a histone deacetylase, (2) the binding of the compound to the histone deacetylase is measured or the change in the activity of the histone deacetylase is measured or the change in the binding of the histone deacetylase to activated glucocorticoid receptor (GR) is measured and (3) any compound capable of the required binding to the histone deacetylase or producing the required change in the activity of the histone deacetylase or its binding to activated glucocorticoid receptor is identified. Methods of treatment make use of compounds identifiable by the screening methods.
申请公布号
WO0167107(A1)
申请公布日期
2001.09.13
申请号
WO2001GB00905
申请日期
2001.03.02
申请人
IMPERIAL COLLEGE INNOVATIONS LIMITED;ADCOCK, IAN, MICHAEL;LIM, SAMSON;ITO, KAZUHIRO;BARNES, PETER, JOHN
发明人
ADCOCK, IAN, MICHAEL;LIM, SAMSON;ITO, KAZUHIRO;BARNES, PETER, JOHN