发明名称 |
PRESENILIN/CRK BINDING POLYPEPTIDES (PCBP) AND METHODS OF USE THEREOF |
摘要 |
The invention provide Presenilin/Crk binding polypeptides characterized by interacting with Presenilin polypeptides, modulating intracellular calcium mobilization, and redistributing from cytoplasm to membrane in the presence of a Presenilin polypeptide. The Presenilin/Crk binding polypeptides are further characterized by interacting with a Crk polypeptide and by containing at least one SH3 domain. Also provided are isolated nucleic acids encoding Presenilin/Crk binding polypeptides, antibodies that bind to Presenilin/Crk binding polypeptides, expression vectors containing Presenilin/Crk binding polynucleotides and host cells transformed by Presenilin/Crk binding polynucleotides. The invention provides a method for identifying a compound that modulates intracellular calcium mobilization and/or modulates Presenilin/Crk binding protein levels or activity. The invention includes a method of treating a disorder associated with Presenilin/Crk binding protein. Also provided is a method of diagnosis of a subject having or at risk of having a disorder of the nervous system such as Alzheimer's disease.
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申请公布号 |
WO0166745(A2) |
申请公布日期 |
2001.09.13 |
申请号 |
WO2001US07024 |
申请日期 |
2001.03.05 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES;SCHUBERT, DAVID, R.;KASHIWA, ATSUSHI;KIMURA, HIDEO |
发明人 |
SCHUBERT, DAVID, R.;KASHIWA, ATSUSHI;KIMURA, HIDEO |
分类号 |
A61K48/00;C07K14/47;C12N15/12;(IPC1-7):C12N15/12;C07K16/18;G01N33/68;A01K67/027;C12N15/00;A61K31/70 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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地址 |
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