| 发明名称 |
DESIGN AND DISCOVERY OF PROTEIN BASED TNF- alpha VARIANTS FOR THE TREATMENT OF TNF- alpha RELATED DISORDERS |
| 摘要 |
The invention relates to novel proteins with TNF- alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF- alpha related disorders, such as rheumatoid arthritis.
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| 申请公布号 |
WO0164889(A2) |
申请公布日期 |
2001.09.07 |
| 申请号 |
WO2001US06848 |
申请日期 |
2001.03.02 |
| 申请人 |
XENCOR |
发明人 |
DAHIYAT, BASSIL, I.;FILIKOV, ANTON |
| 分类号 |
C12N15/09;A61K38/00;A61K38/19;A61P19/00;A61P29/00;C07K14/525;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/28;C12P21/02;(IPC1-7):C12N15/28 |
主分类号 |
C12N15/09 |
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