Method of screening for pharmaceuticals by detecting cross talk between intracellular signals and intranuclear receptors

摘要

Under the knowledge which two kinds of intracellular signal transfer mechanism of TGF-beta super family receptor exist: a pathway via Smad molecule and a pathway via novel MAP kinase such as TAB1 and TAK1, and the knowledge of interaction of Smad molecule with intranuclear receptor or CBP/p300 on the transcription control by Smad molecule, a screening method and a molecular designing method for pharmaceuticals with identified site of action and higher specificity can be accomplished.