| 摘要 |
For example, N- N- (3, 3-dimethylbutyl)-L- alpha -aspartyl-L-phenylalanine methyl ester (A-type crystal) showing characteristic peaks in diffractive X-ray at diffraction angles (2&thetas;, CuK alpha ray) of at least 6.0 DEG , 24.8 DEG . 8.2 DEG and 16.5 DEG is dried to its water content below 3 % by weight. The crystal thus dried is a novel crystal (C-type crystal) of N- N-(3,3-dimethylbutyl)-L- alpha -aspartyl-L-phenylalanine methyl ester excellent in dissolution rate, and when measured by powder X-ray diffractometry, this crystal shows characteristic peaks in diffractive X-ray at diffraction angles (2&thetas;, CuK alpha ray) of at least 7.1 DEG , 19.8 DEG , 17.3 DEG and 17.7 DEG . The dissolution rate (solubility) of the C-type crystals is further improved by converting the crystals into granules. |
