发明名称 |
Method for modulating smooth muscle cell proliferation |
摘要 |
Disclosed is a smooth muscle cell specific promoter, the SM22alpha gene promoter as well as the murine cDNA and genomic SM22alpha nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22alpha promoter.
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申请公布号 |
US6284743(B1) |
申请公布日期 |
2001.09.04 |
申请号 |
US20000546550 |
申请日期 |
2000.04.10 |
申请人 |
ARCH DEVELOPMENT CORPORATION |
发明人 |
PARMACEK MICHAEL S.;SOLWAY JULIAN |
分类号 |
C12N15/09;A61F2/06;A61F2/82;A61K31/7088;A61K35/76;A61K38/00;A61K38/22;A61K38/45;A61K38/55;A61K48/00;A61P9/00;A61P9/10;A61P9/14;A61P11/04;A61P11/06;A61P43/00;C07K14/47;C12N5/10;C12N15/12;(IPC1-7):A61K31/70;C12N5/00;C12P21/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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