MICROBIAL PROCESS FOR PREPARATION OF OPTICALLY ACTIVE 3-HYDROXYPYRROLIDINE DERIVATIVES

摘要

The present invention is directed to a process for the production of compoun ds of the formulae: from a compound of the formula comprising hydroxylating a compound of the formula I in the presence of an enzyme produced by a microorganism of the genera Cunninghamella species or Aspergillus. Preferred microorganisms are Cunninghamella echinulata var. elegans and Aspergillus flavipes. Mixtures of compounds of formulae II and III may also be highly enriched in their composition of compound II by using the enzyme from Cunninghamella echinulat a ATC 8688b.