摘要 |
A compound of formula (I), wherein A represents (II), (III), (IV) or (V), D represents oxygen or sulfur; E represents a single bond, oxygen, sulfur, or NR<10>; R represents hydrogen or methyl; Ar<1> represents a 5- or 6-membered aromatic or heteroaromatic ring containing zero to three nitrogen atoms, zero or one oxygen atom, and zero or one sulfur atom; Ar<2> represents a 5- or 6-membered aromatic or heteroaromatic ring containing zero to three nitrogen atoms, zero or one oxygen atom, and zero or one sulfur atom or; an 8-, 9- or 10-membered fused aromatic or heteroaromatic ring system containing zero to three nitrogen atoms, zero to one oxygen atom, and zero to one sulfur atom; the aromatic rings Ar<1> and Ar<2> are optionally substituted with one or three substituents selected from: halogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, CN, NO2, NR<1>R<2>, CH2NR<1>R<2>, OR<3>, CH2OR<3>, CO2R<4>, CF3; R<1>, R<2> and R<3> are independently C1-4alkyl, aryl, heteroaryl, C(O)R<5>, C(O)NHR<6>, C(O)R<7>, SO2R<8> or R<1> and R<2> may together be (CH2)jG(CH2)k where G is oxygen, sulfur, NR<9>, or a bond; j is 2 to 4; k is 0 to 2; R<4>, R<5>, R<6>, R<7>, R<8>, R<9>, and R<10> are independently C1-4alkyl, aryl, or heteroaryl; or an enantiomer thereof and pharmaceutically acceptable salts thereof; with the provisos that: (1) if D represents oxygen, E represents a single bond, and A represents (II) and either Ar<1> or Ar<2> represents a pyrazole ring, then all optional substituents on the pyrazole ring shall be hydrogen; and (2) if Ar<1> represents a pyridine ring, Ar<2> represents an aryl ring, and A represents (II), then all optional substituents on the pyridine ring shall be hydrogen; and (3) formula (I) does not represent (a); processes for preparing them, pharmaceutical compositions containing them and their use in therapy, especially in the treatment or prophylaxis of psychotic and intellectual impairment disorders. |