| 摘要 |
Compounds of formulawhereinW is -OH or -NHOH;X is a heterocycle with the proviso that when X is a nitrogen containing heterocycle, the heterocycle is attached to the (CH2)m moiety by a ring nitrogen, -CONR2R3, -NR1COR2, -NR1SO2R2, -NR1CONR2R3, -NR1COOR4, heteroarylthio, alkylthio, arylalkylthio, heteroarylalkylthio, heterocycloalkylalkylthio, heterocycloalkylthio or arylthio;Y is carbon, nitrogen, oxygen or sulfur, provided that when Y is carbon, n is 2;Z is alkyl, aryl, alkoxy, aryloxy, aralkoxyaryl, aralkoxyheteroaryl, heteroaryl, heterocycloalkyl, heteroaryloxy, -CONR2R3, -NR1COR2, -NR1CONR2R3, -OCONR2R3, -NR1COOR4, or -SO2R2;R1 is hydrogen, alkyl, heterocycloalkylalkyl, aralkyl or heteroarylalkyl;R2 and R3 are independently R1, aryl or heteroaryl; or R2 and R3 taken together with the nitrogen atom to which they are attached form a 5- to 7-membered ring, which may optionally contain another heteroatom selected from oxygen, nitrogen and sulfur;R4 is alkyl, heterocycloalkylalkyl, aralkyl, aryl or heteroaryl;m represents an integer from one to six;n represents the integer one or two; and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; and a method of inhibiting matrix-degrading metalloproteinases in mammals using such compounds. Compounds of formula I are inhibitors of matrix-degrading metalloproteinases and are useful for the treatment of conditions related thereto.
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