Protein kinase inhibitors for treatment of neurological disorders

摘要

The invention features novel derivatives of K-252a e.g. (II-4) as well as novel bis-N-substituted derivatives of staurosporine of Formula (I). The invention also features a method for treating diseased neuronal cells involving the administration of either the novel staurosporine derivatives or specified functional derivatives of K-252a. In the formula (I): ÄStauÜ - N(CH3)-W-N(CH3)-ÄStauÜ, ÄStauÜ represents a residue of formula (a) and W represents a radical of the formula: -C(=Y)-NH-W'-NH-C(=Y)- where W' is a hydrocarbylene radical of 2-20 carbon atoms and Y is O or S. In formula (II-4) R<1>, R<2>, Z<1> and Z<2> are each H; X is CH2OH; and R is OCH3.