METHOD OF SCREENING ANTIANDROGEN AGENT

摘要

A novel function mechanism wherein an androgen receptor is activated by the interaction between cyclin A and the androgen receptor is found out. This activation is resistant to the existing antiandrogen agents and both of activation depending on the androgen receptor ligand and activation independent therefrom participate in this mechanism. A method of screening an antiandrogen agent with the use of cyclin E is provided. Based on the finding as described above, a novel antiandrogen agent can be screened. This antiandrogen agent is expected as being efficacious against pathologic conditions with the acquisition of resistance to the existing antiandrogen agents, thereby bringing about the potentiality of a novel therapy with the use of antiandrogen agents which has been restricted in the conventional art.