PROCESS FOR THE PREPARATION OF TRIFLUOROTHYMIDINE DERIVATIVES

摘要

1-(2'-Deoxy- beta -D-erythro-pentofuranosyl)-5-trifluoro- methyluracil derivatives having beta -configuration are obtained with high selectivity by reacting 5-trifluoromethyl-2,4-bis- (trimethylsilyloxy)pyrimidine with a 2-deoxy- alpha -D-erythro- pentofuranosyl chloride derivative either in the absence of a solvent or in the presence of a prescribed small amount of a solvent.